Validation of the “QUICK” questionnaire—A tool for diagnosis of “wearing‐off” in patients with Parkinson's disease
Identifieur interne : 002545 ( Main/Exploration ); précédent : 002544; suivant : 002546Validation of the “QUICK” questionnaire—A tool for diagnosis of “wearing‐off” in patients with Parkinson's disease
Auteurs : Pablo Martinez-Martin [Espagne] ; Eduardo Tolosa [Espagne] ; Basilio Hernandez [Espagne] ; Xavier Badia [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-30.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (therapeutic use), Anxiety, Cross-Sectional Studies, Educational Status, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson's disease, Psychiatric Status Rating Scales, Psychometrics, QUICK questionnaire, Questionnaires, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Speech Disorders (etiology), diagnostic validity, screening, wearing‐off.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Speech Disorders.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Aged, Anxiety, Cross-Sectional Studies, Educational Status, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychometrics, Questionnaires, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index.
Abstract
The main objective of the present study was to test the validity of a 19‐items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty‐two patients (36.0% without WO; 64.0% with mild or moderate/severe WO) were included. Diagnosis of WO by the participant neurologist was considered the “gold standard.” The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale‐Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut‐off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86–0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21944
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The main objective of the present study was to test the validity of a 19‐items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty‐two patients (36.0% without WO; 64.0% with mild or moderate/severe WO) were included. Diagnosis of WO by the participant neurologist was considered the “gold standard.” The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale‐Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut‐off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86–0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO. © 2008 Movement Disorder Society</div>
</front>
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<name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name>
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